Classification of lyophilised mixtures using multivariate analysis of NIR spectra
نویسندگان
چکیده
منابع مشابه
Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy.
The ratio between mannitol and sucrose in a freeze-dried formulation has a major impact on the processing and the stability of a lyophilised product. The ratio of these common excipients influences a critical quality attribute of the system, namely the overall amount of water, due to the different nature of their water-solid interactions. For this experiment samples containing various ratios of...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2010
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2009.06.016